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Dokumenttyp:
journal article 
Autor(en):
Liu, SY; Liang, QJ; Lin, TX; Fan, XL; Liang, Y; Heemann, U; Li, Y 
Titel:
Lipopolysaccharide-enhanced early proliferation of insulin secreting NIT-1 cell is associated with nuclear factor-kappaB- mediated inhibition of caspase 3 cleavage. 
Abstract:
Increased levels of plasma lipopolysaccharide (LPS) have been found in obesity and diabetes patients. This study was to investigate the effect of LPS on pancreatic beta-cell viability and the involvement of caspase 3 in NIT-1 cell line.Mouse insulinoma NIT-1 cells were treated with LPS for the indicated time and dose. Cell viability was measured by cell counting kit-8 reagent. Toll-like receptor 4 (TLR4), caspase 3 and cleaved caspase 3 were detected by Western blotting. Insulin was determined b...    »
 
Zeitschriftentitel:
Chin Med J (Engl) 
Jahr:
2011 
Band / Volume:
124 
Heft / Issue:
22 
Seitenangaben Beitrag:
3652-6 
Sprache:
eng 
Print-ISSN:
0366-6999 
TUM Einrichtung:
r Nephrologie