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Dokumenttyp:
journal article 
Autor(en):
Toller, IM; Neelsen, KJ; Steger, M; Hartung, ML; Hottiger, MO; Stucki, M; Kalali, B; Gerhard, M; Sartori, AA; Lopes, M; Müller, A 
Titel:
Carcinogenic bacterial pathogen Helicobacter pylori triggers DNA double-strand breaks and a DNA damage response in its host cells. 
Abstract:
The bacterial pathogen Helicobacter pylori chronically infects the human gastric mucosa and is the leading risk factor for the development of gastric cancer. The molecular mechanisms of H. pylori-associated gastric carcinogenesis remain ill defined. In this study, we examined the possibility that H. pylori directly compromises the genomic integrity of its host cells. We provide evidence that the infection introduces DNA double-strand breaks (DSBs) in primary and transformed murine and human epit...    »
 
Zeitschriftentitel:
Proc Natl Acad Sci U S A 
Jahr:
2011 
Band / Volume:
108 
Heft / Issue:
36 
Seitenangaben Beitrag:
14944-9 
Sprache:
eng 
Print-ISSN:
0027-8424 
TUM Einrichtung:
r Medizinische Mikrobiologie, Immunologie und Hygiene