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Dokumenttyp:
journal article 
Autor(en):
Häcker, H; Redecke, V; Blagoev, B; Kratchmarova, I; Hsu, LC; Wang, GG; Kamps, MP; Raz, E; Wagner, H; Häcker, G; Mann, M; Karin, M 
Titel:
Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6. 
Abstract:
Toll-like receptors (TLRs) are activated by pathogen-associated molecular patterns to induce innate immune responses and production of pro-inflammatory cytokines, interferons and anti-inflammatory cytokines. TLRs activate downstream effectors through adaptors that contain Toll/interleukin-1 receptor (TIR) domains, but the mechanisms accounting for diversification of TLR effector functions are unclear. To dissect biochemically TLR signalling, we established a system for isolating signalling compl...    »
 
Zeitschriftentitel:
Nature 
Jahr:
2006 
Band / Volume:
439 
Heft / Issue:
7073 
Seitenangaben Beitrag:
204-7 
Sprache:
eng 
Print-ISSN:
0028-0836 
TUM Einrichtung:
r Medizinische Mikrobiologie, Immunologie und Hygiene