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Document type:
journal article 
Author(s):
Häcker, H; Redecke, V; Blagoev, B; Kratchmarova, I; Hsu, LC; Wang, GG; Kamps, MP; Raz, E; Wagner, H; Häcker, G; Mann, M; Karin, M 
Title:
Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6. 
Abstract:
Toll-like receptors (TLRs) are activated by pathogen-associated molecular patterns to induce innate immune responses and production of pro-inflammatory cytokines, interferons and anti-inflammatory cytokines. TLRs activate downstream effectors through adaptors that contain Toll/interleukin-1 receptor (TIR) domains, but the mechanisms accounting for diversification of TLR effector functions are unclear. To dissect biochemically TLR signalling, we established a system for isolating signalling compl...    »
 
Journal title abbreviation:
Nature 
Year:
2006 
Journal volume:
439 
Journal issue:
7073 
Pages contribution:
204-7 
Language:
eng 
Print-ISSN:
0028-0836 
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene