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Dokumenttyp:
journal article 
Autor(en):
Scheel, B; Teufel, R; Probst, J; Carralot, JP; Geginat, J; Radsak, M; Jarrossay, D; Wagner, H; Jung, G; Rammensee, HG; Hoerr, I; Pascolo, S 
Titel:
Toll-like receptor-dependent activation of several human blood cell types by protamine-condensed mRNA. 
Abstract:
We reported that RNA condensed on protamine is protected from RNase-mediated degradation and can be used for vaccination. Here, we show that such complexes are also danger signals that activate mouse cells through a MyD88-dependent pathway. Moreover, mRNA-protamine complexes stimulate human blood cells. They strongly activate DC and monocytes, leading to TNF-alpha and IFN-alpha secretion. In addition, protamine-RNA complexes directly activate B cells, NK cells and granulocytes. The detailed anal...    »
 
Zeitschriftentitel:
Eur J Immunol 
Jahr:
2005 
Band / Volume:
35 
Heft / Issue:
Seitenangaben Beitrag:
1557-66 
Sprache:
eng 
Print-ISSN:
0014-2980 
TUM Einrichtung:
r Medizinische Mikrobiologie, Immunologie und Hygiene