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Dokumenttyp:
journal article 
Autor(en):
Fischer, SF; Rehm, M; Bauer, A; Höfling, F; Kirschnek, S; Rutz, M; Bauer, S; Wagner, H; Häcker, G 
Titel:
Toll-like receptor 9 signaling can sensitize fibroblasts for apoptosis. 
Abstract:
Toll-like receptors (TLR) are activated by microbial components and transmit signals that induce cell activation and differentiation. A number of recent reports further indicate that TLR also have the potential to induce apoptosis upon ligand binding. Here we investigate the apoptosis-inducing capacity of TLR9, the receptor for microbial CpG-DNA. Unlike ligands for TLR2 and TLR4, CpG-DNA failed to induce apoptosis in RAW264.7 mouse macrophages. In human embryonic kidney fibroblasts transfected s...    »
 
Zeitschriftentitel:
Immunol Lett 
Jahr:
2005 
Band / Volume:
97 
Heft / Issue:
Seitenangaben Beitrag:
115-22 
Sprache:
eng 
Print-ISSN:
0165-2478 
TUM Einrichtung:
r Medizinische Mikrobiologie, Immunologie und Hygiene