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- Document type:
- Journal Article
- Author(s):
- Wang, X; Ma, Y; Weis, JH; Zachary, JF; Kirschning, CJ; Weis, JJ
- Title:
- Relative contributions of innate and acquired host responses to bacterial control and arthritis development in Lyme disease.
- Abstract:
- TLR2(-/-)/scid double-mutant mice were infected with B. burgdorferi to assess the relative importance of acquired and innate host defenses. Although spirochete levels at 4 weeks were lower in TLR2(-/-) mice than in TLR2(-/-)/scid mice, the increased arthritis severity of TLR2 (Toll-like receptor 2)-deficient mice was reduced by the presence of the scid mutation.
- Journal title abbreviation:
- Infect Immun
- Year:
- 2005
- Journal volume:
- 73
- Journal issue:
- 1
- Pages contribution:
- 657-60
- Language:
- eng
- Fulltext / DOI:
- doi:10.1128/IAI.73.1.657-660.2005
- Pubmed ID:
- http://view.ncbi.nlm.nih.gov/pubmed/15618212
- Print-ISSN:
- 0019-9567
- TUM Institution:
- Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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