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Dokumenttyp:
journal article 
Autor(en):
Rodriguez, N; Fend, F; Jennen, L; Schiemann, M; Wantia, N; Prazeres da Costa, CU; Dürr, S; Heinzmann, U; Wagner, H; Miethke, T 
Titel:
Polymorphonuclear neutrophils improve replication of Chlamydia pneumoniae in vivo upon MyD88-dependent attraction. 
Abstract:
Chlamydia pneumoniae, an obligate intracellular bacterium, causes pneumonia in humans and mice. In this study, we show that GR1+/CD45+ polymorphonuclear neutrophils (PMN) surprisingly increase the bacterial load of C. pneumoniae in vivo. Upon intranasal infection of wild-type mice, the lung weight is increased; the cytokines TNF, IL-12p40, and IFN-gamma, as well as the chemokines keratinocyte-derived chemokine, MCP-1, and MIP-2 are secreted; and GR1+/CD45+ PMN are recruited into lungs 3 days p...    »
 
Zeitschriftentitel:
J Immunol 
Jahr:
2005 
Band / Volume:
174 
Heft / Issue:
Seitenangaben Beitrag:
4836-44 
Sprache:
eng 
Print-ISSN:
0022-1767 
TUM Einrichtung:
r Medizinische Mikrobiologie, Immunologie und Hygiene; r Allgemeine Pathologie und pathologische Anatomie