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Document type:
journal article 
Author(s):
De Wit, D; Olislagers, V; Goriely, S; Vermeulen, F; Wagner, H; Goldman, M; Willems, F 
Title:
Blood plasmacytoid dendritic cell responses to CpG oligodeoxynucleotides are impaired in human newborns. 
Abstract:
Plasmacytoid dendritic cells (pDCs) respond to unmethylated cytosine-phosphate-guanosine (CpG) motifs present in bacterial DNA or unmethylated synthetic oligodeoxynucleotides (CpG). In order to assess the function of pDCs in human newborns, interferon-alpha (IFN-alpha) production induced by CpG 2216 and phenotypic maturation of pDCs in response to CpG 2006 were compared in cord blood and adult blood. We first observed that neonatal pDCs displayed decreased up-regulation of CD80, CD83, CD86, and...    »
 
Journal title abbreviation:
Blood 
Year:
2004 
Journal volume:
103 
Journal issue:
Pages contribution:
1030-2 
Language:
eng 
Print-ISSN:
0006-4971 
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene