Benutzer: Gast  Login
Dokumenttyp:
journal article 
Autor(en):
Cramer, T; Yamanishi, Y; Clausen, BE; Förster, I; Pawlinski, R; Mackman, N; Haase, VH; Jaenisch, R; Corr, M; Nizet, V; Firestein, GS; Gerber, HP; Ferrara, N; Johnson, RS 
Titel:
HIF-1alpha is essential for myeloid cell-mediated inflammation. 
Abstract:
Granulocytes and monocytes/macrophages of the myeloid lineage are the chief cellular agents of innate immunity. Here, we have examined the inflammatory response in mice with conditional knockouts of the hypoxia responsive transcription factor HIF-1alpha, its negative regulator VHL, and a known downstream target, VEGF. We find that activation of HIF-1alpha is essential for myeloid cell infiltration and activation in vivo through a mechanism independent of VEGF. Loss of VHL leads to a large increa...    »
 
Zeitschriftentitel:
Cell 
Jahr:
2003 
Band / Volume:
112 
Heft / Issue:
Seitenangaben Beitrag:
645-57 
Sprache:
eng 
Print-ISSN:
0092-8674 
TUM Einrichtung:
r Medizinische Mikrobiologie, Immunologie und Hygiene