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Dokumenttyp:
journal article 
Autor(en):
Kwok, LY; Lütjen, S; Soltek, S; Soldati, D; Busch, D; Deckert, M; Schlüter, D 
Titel:
The induction and kinetics of antigen-specific CD8 T cells are defined by the stage specificity and compartmentalization of the antigen in murine toxoplasmosis. 
Abstract:
Toxoplasma gondii forms different life stages, fast-replicating tachyzoites and slow-growing bradyzoites, in mammalian hosts. CD8 T cells are of crucial importance in toxoplasmosis, but it is unknown which parasite stage is recognized by CD8 T cells. To analyze stage-specific CD8 T cell responses, we generated various recombinant Toxoplasma gondii expressing the heterologous Ag beta-galactosidase (beta-gal) and studied whether 1) secreted or cytoplasmic Ags and 2) tachyzoites or bradyzoites, whi...    »
 
Zeitschriftentitel:
J Immunol 
Jahr:
2003 
Band / Volume:
170 
Heft / Issue:
Seitenangaben Beitrag:
1949-57 
Sprache:
eng 
Print-ISSN:
0022-1767 
TUM Einrichtung:
r Medizinische Mikrobiologie, Immunologie und Hygiene