Benutzer: Gast  Login
Dokumenttyp:
journal article 
Autor(en):
Glogauer, M; Marchal, CC; Zhu, F; Worku, A; Clausen, BE; Foerster, I; Marks, P; Downey, GP; Dinauer, M; Kwiatkowski, DJ 
Titel:
Rac1 deletion in mouse neutrophils has selective effects on neutrophil functions. 
Abstract:
Defects in myeloid cell function in Rac2 knockout mice underline the importance of this isoform in activation of NADPH oxidase and cell motility. However, the specific role of Rac1 in neutrophil function has been difficult to assess since deletion of Rac1 results in embryonic lethality in mice. To elucidate the specific role of Rac1 in neutrophils, we generated mice with a conditional Rac1 deficiency restricted to cells of the granulocyte/monocyte lineage. As observed in Rac2-deficient neutrophi...    »
 
Zeitschriftentitel:
J Immunol 
Jahr:
2003 
Band / Volume:
170 
Heft / Issue:
11 
Seitenangaben Beitrag:
5652-7 
Sprache:
eng 
Print-ISSN:
0022-1767 
TUM Einrichtung:
r Medizinische Mikrobiologie, Immunologie und Hygiene