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Dokumenttyp:
journal article 
Autor(en):
Rutz, M; Metzger, J; Gellert, T; Luppa, P; Lipford, GB; Wagner, H; Bauer, S 
Titel:
Toll-like receptor 9 binds single-stranded CpG-DNA in a sequence- and pH-dependent manner. 
Abstract:
Toll-like receptors (TLR) recognize bacterial and viral components, but direct interaction of receptor and ligand is unclear. Here, we demonstrate that TLR9 binds directly and sequence-specifically to single-stranded unmethylated CpG-DNA containing a phosphodiester backbone. TLR9-CpG-DNA interaction occurs at the acidic pH (6.5-5.0) found in endosomes and lysosomes. By sequence comparison we identified a potential CpG-DNA binding domain homologous to that described for methyl-CpG-DNA binding pro...    »
 
Zeitschriftentitel:
Eur J Immunol 
Jahr:
2004 
Band / Volume:
34 
Heft / Issue:
Seitenangaben Beitrag:
2541-50 
Sprache:
eng 
Print-ISSN:
0014-2980 
TUM Einrichtung:
r Medizinische Mikrobiologie, Immunologie und Hygiene; r Klinische Chemie und Pathobiochemie