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Dokumenttyp:
journal article 
Autor(en):
Pospisil, H; Herrmann, A; Butherus, K; Pirson, S; Reich, JG; Kemmner, W 
Titel:
Verification of predicted alternatively spliced Wnt genes reveals two new splice variants (CTNNB1 and LRP5) and altered Axin-1 expression during tumour progression. 
Abstract:
BACKGROUND: Splicing processes might play a major role in carcinogenesis and tumour progression. The Wnt pathway is of crucial relevance for cancer progression. Therefore we focussed on the Wnt/beta-catenin signalling pathway in order to validate the expression of sequences predicted as alternatively spliced by bioinformatic methods. Splice variants of its key molecules were selected, which may be critical components for the understanding of colorectal tumour progression and may have the potenti...    »
 
Zeitschriftentitel:
BMC Genomics 
Jahr:
2006 
Band / Volume:
Seitenangaben Beitrag:
148 
Sprache:
eng 
TUM Einrichtung:
Kinderklinik und Poliklinik