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Dokumenttyp:
journal article 
Autor(en):
Feederle, R; Neuhierl, B; Baldwin, G; Bannert, H; Hub, B; Mautner, J; Behrends, U; Delecluse, HJ 
Titel:
Epstein-Barr virus BNRF1 protein allows efficient transfer from the endosomal compartment to the nucleus of primary B lymphocytes. 
Abstract:
Epstein-Barr virus (EBV) is a tumor virus with marked B lymphotropism. After crossing the B-cell membrane, the virus enters cytoplasmic vesicles, where decapsidation takes place to allow transfer of the viral DNA to the cell nucleus. BNRF1 has been characterized as the EBV major tegument protein, but its precise function is unknown. We have constructed a viral mutant that lacks the BNRF1 gene and report here its in vitro phenotype. A recombinant virus devoid of BNRF1 (DeltaBNRF1) showed efficien...    »
 
Zeitschriftentitel:
J Virol 
Jahr:
2006 
Band / Volume:
80 
Heft / Issue:
19 
Seitenangaben Beitrag:
9435-43 
Sprache:
eng 
Print-ISSN:
0022-538X 
TUM Einrichtung:
Kinderklinik und Poliklinik