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Dokumenttyp:
journal article 
Autor(en):
Scherf, W; Burdach, S; Hansen, G 
Titel:
Reduced expression of transforming growth factor beta 1 exacerbates pathology in an experimental asthma model. 
Abstract:
Allergic asthma is characterized by airway hyperreactivity (AHR), eosinophilic airway inflammation and elevated serum IgE levels. T-helper 2 (Th2) cells play a critical role in the pathogenesis of asthma, but the immunological mechanisms that inhibit Th2 cell function in vivo are not well understood. Conflicting results regarding the protective role of Th1 cytokines and TGF-beta in asthma have been reported. To further investigate the role of TGF-beta(1 )in asthma, we examined mice heterozygous...    »
 
Zeitschriftentitel:
Eur J Immunol 
Jahr:
2005 
Band / Volume:
35 
Heft / Issue:
Seitenangaben Beitrag:
198-206 
Sprache:
eng 
Print-ISSN:
0014-2980 
TUM Einrichtung:
Kinderklinik und Poliklinik