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Dokumenttyp:
journal article 
Autor(en):
Klingenberg, R; Autschbach, F; Gleissner, C; Giese, T; Wambsganss, N; Sommer, N; Richter, G; Katus, HA; Dengler, TJ 
Titel:
Endothelial inducible costimulator ligand expression is increased during human cardiac allograft rejection and regulates endothelial cell-dependent allo-activation of CD8+ T cells in vitro. 
Abstract:
The role of costimulatory molecules other than CD80/CD86 in endothelial cell (EC)-dependent CD8(+) T cell activation including the generation of a distinct subset of endothelium-specific CTL (EC-CTL) remains unclear. Inducible costimulator (ICOS) and its ligand (ICOSL) are new members of the CD28 family mediating effector T cell differentiation and graft rejection in animal models. In this study endothelial ICOSL expression/regulation and effects on CD8(+) T cell allo-activation were analyzed. C...    »
 
Zeitschriftentitel:
Eur J Immunol 
Jahr:
2005 
Band / Volume:
35 
Heft / Issue:
Seitenangaben Beitrag:
1712-21 
Sprache:
eng 
Print-ISSN:
0014-2980 
TUM Einrichtung:
Kinderklinik und Poliklinik