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Dokumenttyp:
journal article 
Autor(en):
Westermann, J; Nguyen-Hoai, T; Mollweide, A; Richter, G; Schmetzer, O; Kim, HJ; Blankenstein, T; Dörken, B; Pezzutto, A 
Titel:
Flt-3 ligand as adjuvant for DNA vaccination augments immune responses but does not skew TH1/TH2 polarization. 
Abstract:
Since transfection of dendritic cells (DC) plays a key role in DNA vaccination, in vivo expansion of DC might be a tool to increase vaccine efficacy. We asked whether Fms-like tyrosine kinase-3 ligand (Flt-3L), a growth factor for DC, can be used as an adjuvant for DNA vaccination. Beta-galactosidase (beta-gal) was used as a model antigen in C57BL/6 mice. Mice were immunized i.m. with DNA coding for beta-gal with or without additional injection of Flt-3L. In both cases, antigen-specific CD4+ and...    »
 
Zeitschriftentitel:
Gene Ther 
Jahr:
2004 
Band / Volume:
11 
Heft / Issue:
13 
Seitenangaben Beitrag:
1048-56 
Sprache:
eng 
Print-ISSN:
0969-7128 
TUM Einrichtung:
Kinderklinik und Poliklinik