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Dokumenttyp:
journal article 
Autor(en):
Vallon, V; Wyatt, AW; Klingel, K; Huang, DY; Hussain, A; Berchtold, S; Friedrich, B; Grahammer, F; Belaiba, RS; Görlach, A; Wulff, P; Daut, J; Dalton, ND; Ross, J; Flögel, U; Schrader, J; Osswald, H; Kandolf, R; Kuhl, D; Lang, F 
Titel:
SGK1-dependent cardiac CTGF formation and fibrosis following DOCA treatment. 
Abstract:
The mineralocorticoids aldosterone and deoxycorticosterone acetate (DOCA) stimulate renal tubular salt reabsorption, increase salt appetite, induce extracellular volume expansion, and elevate blood pressure. Cardiac effects of mineralocorticoids include stimulation of matrix protein deposition leading to cardiac fibrosis, which is at least partially due to the direct action of the hormones on cardiac cells. The signaling mechanisms mediating mineralocorticoid-induced cardiac fibrosis have so far...    »
 
Zeitschriftentitel:
J Mol Med 
Jahr:
2006 
Band / Volume:
84 
Heft / Issue:
Seitenangaben Beitrag:
396-404 
Sprache:
eng 
Print-ISSN:
0946-2716 
TUM Einrichtung:
r Kinderkardiologie und angeborene Herzfehler