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Dokumenttyp:
journal article 
Autor(en):
Kuhn, KA; Kulik, L; Tomooka, B; Braschler, KJ; Arend, WP; Robinson, WH; Holers, VM 
Titel:
Antibodies against citrullinated proteins enhance tissue injury in experimental autoimmune arthritis. 
Abstract:
Antibodies against citrullinated proteins are specific and predictive markers for rheumatoid arthritis although the pathologic relevance of these antibodies remains unclear. To investigate the significance of these autoantibodies, collagen-induced arthritis (CIA) in mice was used to establish an animal model of antibody reactivity to citrullinated proteins. DBA/1J mice were immunized with bovine type II collagen (CII) at days 0 and 21, and serum was collected every 7 days for analysis. Antibodie...    »
 
Zeitschriftentitel:
J Clin Invest 
Jahr:
2006 
Band / Volume:
116 
Heft / Issue:
Seitenangaben Beitrag:
961-73 
Sprache:
eng 
Print-ISSN:
0021-9738 
TUM Einrichtung:
r Medizinische Statistik und Epidemiologie