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Dokumenttyp:
journal article 
Autor(en):
Riemenschneider, M; Konta, L; Friedrich, P; Schwarz, S; Taddei, K; Neff, F; Padovani, A; Kölsch, H; Laws, SM; Klopp, N; Bickeböller, H; Wagenpfeil, S; Mueller, JC; Rosenberger, A; Diehl-Schmid, J; Archetti, S; Lautenschlager, N; Borroni, B; Müller, U; Illig, T; Heun, R; Egensperger, R; Schlegel, J; Förstl, H; Martins, RN; Kurz, A 
Titel:
A functional polymorphism within plasminogen activator urokinase (PLAU) is associated with Alzheimer's disease. 
Abstract:
A number of susceptibility loci for Alzheimer's disease (AD) have been identified including a region on Chromosome 10q21-q22. Within this region the plasminogen activator urokinase gene (PLAU) was considered as a reasonable candidate from its functional implication in plasmin generation, a serine protease capable of degrading beta-Amyloid (Abeta) protein. We screened 56 single nucleotide polymorphisms (SNPs) around PLAU using 1751 individuals from four independent case-control samples (Munich, N...    »
 
Zeitschriftentitel:
Hum Mol Genet 
Jahr:
2006 
Band / Volume:
15 
Heft / Issue:
16 
Seitenangaben Beitrag:
2446-56 
Sprache:
eng 
Print-ISSN:
0964-6906 
TUM Einrichtung:
r Psychiatrie und Psychotherapie; r Allgemeine Pathologie und pathologische Anatomie; r Medizinische Statistik und Epidemiologie