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Dokumenttyp:
journal article 
Autor(en):
Fanara, P; Turner, S; Busch, R; Killion, S; Awada, M; Turner, H; Mahsut, A; Laprade, KL; Stark, JM; Hellerstein, MK 
Titel:
In vivo measurement of microtubule dynamics using stable isotope labeling with heavy water. Effect of taxanes. 
Abstract:
Microtubules are dynamic polymers with central roles in the mitotic checkpoint, mitotic spindle assembly, and chromosome segregation. Agents that block mitotic progression and cell proliferation by interfering with microtubule dynamics (microtubule-targeted tubulin-polymerizing agents (MTPAs)) are powerful antitumor agents. Effects of MTPAs (e.g. paclitaxel) on microtubule dynamics have not yet been directly demonstrated in intact animals, however. Here we describe a method that measures microtu...    »
 
Zeitschriftentitel:
J Biol Chem 
Jahr:
2004 
Band / Volume:
279 
Heft / Issue:
48 
Seitenangaben Beitrag:
49940-7 
Sprache:
eng 
Print-ISSN:
0021-9258 
TUM Einrichtung:
r Medizinische Statistik und Epidemiologie