Benutzer: Gast  Login
Dokumenttyp:
journal article 
Autor(en):
Kancha, RK; Peschel, C; Duyster, J 
Titel:
The epidermal growth factor receptor-L861Q mutation increases kinase activity without leading to enhanced sensitivity toward epidermal growth factor receptor kinase inhibitors. 
Abstract:
Mutations in the epidermal growth factor receptor (EGFR) kinase domain such as EGFR-L858R and EGFR-G719S have been reported to activate the kinase and also sensitize a subset of patients with non-small cell lung cancer to EGFR kinase inhibitor treatment. Nevertheless, for other common point mutations such as EGFR-L861Q, it is unclear whether and to what extent they sensitize toward gefitinib and erlotinib. Thus far, there is no reliable cellular assay to compare in a ligand-independent manner in...    »
 
Zeitschriftentitel:
J Thorac Oncol 
Jahr:
2011 
Band / Volume:
Heft / Issue:
Seitenangaben Beitrag:
387-92 
Sprache:
eng 
Print-ISSN:
1556-0864 
TUM Einrichtung:
III. Medizinische Klinik und Poliklinik