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Dokumenttyp:
journal article 
Autor(en):
Hornung, Veit, V; Ellegast, Jana, J; Kim, Sarah, S; Brzózka, Krzysztof, K; Jung, Andreas, A; Kato, Hiroki, H; Poeck, Hendrik, H; Akira, Shizuo, S; Conzelmann, Karl-Klaus, KK; Schlee, Martin, M; Endres, Stefan, S; Hartmann, Gunther, G 
Titel:
5'-Triphosphate RNA is the ligand for RIG-I. 
Abstract:
The structural basis for the distinction of viral RNA from abundant self RNA in the cytoplasm of virally infected cells is largely unknown. We demonstrated that the 5'-triphosphate end of RNA generated by viral polymerases is responsible for retinoic acid-inducible protein I (RIG-I)-mediated detection of RNA molecules. Detection of 5'-triphosphate RNA is abrogated by capping of the 5'-triphosphate end or by nucleoside modification of RNA, both occurring during posttranscriptional RNA processing...    »
 
Zeitschriftentitel:
Science 
Jahr:
2006 
Band / Volume:
314 
Heft / Issue:
5801 
Seitenangaben Beitrag:
994-7 
Sprache:
eng 
Print-ISSN:
0036-8075 
TUM Einrichtung:
III. Medizinische Klinik und Poliklinik