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Dokumenttyp:
journal article 
Autor(en):
Pedranzini, L; Dechow, T; Berishaj, M; Comenzo, R; Zhou, P; Azare, J; Bornmann, W; Bromberg, J 
Titel:
Pyridone 6, a pan-janus-activated kinase inhibitor, induces growth inhibition of multiple myeloma cells. 
Abstract:
Interleukin-6 (IL-6) and the subsequent Janus-activated kinase (JAK)-dependent signaling pathways play a critical role in the pathogenesis of multiple myeloma. Here, we compared the sensitivity and specificity of a novel pan-JAK inhibitor, tetracyclic pyridone 6 (P6), with that of AG490 in a panel of myeloma-derived cell lines. P6 induced growth arrest and subsequent apoptosis of the IL-6-dependent hybridoma and myeloma-derived cell lines (B9 and INA-6) grown either in IL-6-containing medium or...    »
 
Zeitschriftentitel:
Cancer Res 
Jahr:
2006 
Band / Volume:
66 
Heft / Issue:
19 
Seitenangaben Beitrag:
9714-21 
Sprache:
eng 
Print-ISSN:
0008-5472 
TUM Einrichtung:
III. Medizinische Klinik und Poliklinik