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Document type:
journal article 
Author(s):
Aapro, MS; Grunberg, SM; Manikhas, GM; Olivares, G; Suarez, T; Tjulandin, SA; Bertoli, LF; Yunus, F; Morrica, B; Lordick, F; Macciocchi, A 
Title:
A phase III, double-blind, randomized trial of palonosetron compared with ondansetron in preventing chemotherapy-induced nausea and vomiting following highly emetogenic chemotherapy. 
Abstract:
BACKGROUND: This pivotal phase III trial evaluated the efficacy and safety of palonosetron in preventing acute and delayed chemotherapy-induced nausea and vomiting (CINV) following highly emetogenic chemotherapy (HEC). PATIENTS AND METHODS: Patients were randomized to a single intravenous dose of palonosetron 0.25 mg or 0.75 mg, or ondansetron 32 mg prior to HEC. Dexamethasone pre-treatment (with stratification) was used at investigator discretion. The primary efficacy endpoint was the proportio...    »
 
Journal title abbreviation:
Ann Oncol 
Year:
2006 
Journal volume:
17 
Journal issue:
Pages contribution:
1441-9 
Language:
eng 
Print-ISSN:
0923-7534 
TUM Institution:
III. Medizinische Klinik und Poliklinik