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Dokumenttyp:
journal article 
Autor(en):
Nilsson, JA; Keller, UB; Baudino, TA; Yang, C; Norton, S; Old, JA; Nilsson, LM; Neale, G; Kramer, DL; Porter, CW; Cleveland, JL 
Titel:
Targeting ornithine decarboxylase in Myc-induced lymphomagenesis prevents tumor formation. 
Abstract:
Checkpoints that control Myc-mediated proliferation and apoptosis are bypassed during tumorigenesis. Genes encoding polyamine biosynthetic enzymes are overexpressed in B cells from E mu-Myc transgenic mice. Here, we report that disabling one of these Myc targets, Ornithine decarboxylase (Odc), abolishes Myc-induced suppression of the Cdk inhibitors p21(Cip1) and p27(Kip1), thereby impairing Myc's proliferative, but not apoptotic, response. Moreover, lymphoma development was markedly delayed in E...    »
 
Zeitschriftentitel:
Cancer Cell 
Jahr:
2005 
Band / Volume:
Heft / Issue:
Seitenangaben Beitrag:
433-44 
Sprache:
eng 
Print-ISSN:
1535-6108 
TUM Einrichtung:
III. Medizinische Klinik und Poliklinik