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Dokumenttyp:
journal article 
Autor(en):
Urschel, S; Bassermann, F; Bai, RY; Münch, S; Peschel, C; Duyster, J 
Titel:
Phosphorylation of grb10 regulates its interaction with 14-3-3. 
Abstract:
Grb10 is a member of adapter proteins that are thought to play a role in receptor tyrosine kinase-mediated signal transduction. Grb10 expression levels can influence Akt activity, and Grb10 may act as an adapter involved in the relocalization of Akt to the cell membrane. Here we identified 14-3-3 as a binding partner of Grb10 by employing a yeast two-hybrid screen. The 14-3-3.Grb10 interaction requires phosphorylation of Grb10, and only the phosphorylated form of Grb10 co-immunoprecipitates with...    »
 
Zeitschriftentitel:
J Biol Chem 
Jahr:
2005 
Band / Volume:
280 
Heft / Issue:
17 
Seitenangaben Beitrag:
16987-93 
Sprache:
eng 
Print-ISSN:
0021-9258 
TUM Einrichtung:
III. Medizinische Klinik und Poliklinik