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Dokumenttyp:
journal article 
Autor(en):
Schliep, S; Decker, T; Schneller, F; Wagner, H; Häcker, G 
Titel:
Functional evaluation of the role of inhibitor of apoptosis proteins in chronic lymphocytic leukemia. 
Abstract:
OBJECTIVE: The slow accumulation of malignant cells in chronic lymphocytic leukemia (CLL) suggests a defect in the induction of apoptosis in these cells. Previous studies have found sporadic alterations in the apoptotic apparatus in CLL cells, but a widespread defect has not been detected until now. A crucial checkpoint in the progression of apoptosis is the activity of inhibitor of apoptosis proteins (IAP) that control the activity of caspases upon the release of cytochrome c from mitochondria....    »
 
Zeitschriftentitel:
Exp Hematol 
Jahr:
2004 
Band / Volume:
32 
Heft / Issue:
Seitenangaben Beitrag:
556-62 
Sprache:
eng 
Print-ISSN:
0301-472X 
TUM Einrichtung:
r Medizinische Mikrobiologie, Immunologie und Hygiene; III. Medizinische Klinik und Poliklinik