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Document type:
journal article 
Author(s):
Olszewska, W; Suezer, Y; Sutter, G; Openshaw, PJ 
Title:
Protective and disease-enhancing immune responses induced by recombinant modified vaccinia Ankara (MVA) expressing respiratory syncytial virus proteins. 
Abstract:
Modified vaccinia Ankara (MVA) recombinants expressing single or multiple RSV surface proteins (F or G) are promising potential vaccines. We studied humoral and cellular responses induced by MVA-F and MVA-G in mice, comparing them to a formalin inactivated RSV preparation (FI-RSV) known to increase disease severity. MVA-F or MVA-G vaccination enhanced weight loss during RSV challenge, but did not show the lung eosinophilia seen after FI-RSV vaccination. FI-RSV induced a stronger total RSV IgG re...    »
 
Journal title abbreviation:
Vaccine 
Year:
2004 
Journal volume:
23 
Journal issue:
Pages contribution:
215-21 
Language:
eng 
Print-ISSN:
0264-410X 
TUM Institution:
Institut für Virologie