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Document type:
journal article 
Author(s):
Lotz, C; Ferreira, EA; Drexler, I; Mutallib, SA; Huber, C; Sutter, G; Theobald, M 
Title:
Partial tyrosinase-specific self tolerance by HLA-A*0201-restricted cytotoxic T lymphocytes in mice and man. 
Abstract:
The human tyrosinase (hTyr) (369-377) cytotoxic T lymphocyte (CTL) epitope is presented by malignant melanoma and various nontransformed cells in association with human leukocyte antigen (HLA)-A*0201 (A2.1) and used for vaccination-based immunotherapy of melanoma patients. Its mouse homologue, mTyr (369-377), is naturally processed and bound by A2.1 with equivalent efficacy and thus enabled us to explore the effect of self tolerance on Tyr-specific T cells in different lines of A2.1 transgenic (...    »
 
Journal title abbreviation:
Int J Cancer 
Year:
2004 
Journal volume:
108 
Journal issue:
Pages contribution:
571-9 
Language:
eng 
Print-ISSN:
0020-7136 
TUM Institution:
Institut für Virologie