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Dokumenttyp:
journal article 
Autor(en):
Hsu, EC; Hsi, B; Hirota-Tsuchihara, M; Ruland, J; Iorio, C; Sarangi, F; Diao, J; Migliaccio, G; Tyrrell, DL; Kneteman, N; Richardson, CD 
Titel:
Modified apoptotic molecule (BID) reduces hepatitis C virus infection in mice with chimeric human livers. 
Abstract:
Hepatitis C virus (HCV) encodes a polyprotein consisting of core, envelope (E1, E2, p7), and nonstructural polypeptides (NS2, NS3, NS4A, NS4B, NS5A, NS5B). The serine protease (NS3/NS4A), helicase (NS3), and polymerase (NS5B) constitute valid targets for antiviral therapy. We engineered BH3 interacting domain death agonist (BID), an apoptosis-inducing molecule, to contain a specific cleavage site recognized by the NS3/NS4A protease. Cleavage of the BID precursor molecule by the viral protease ac...    »
 
Zeitschriftentitel:
Nat Biotechnol 
Jahr:
2003 
Band / Volume:
21 
Heft / Issue:
Seitenangaben Beitrag:
519-25 
Sprache:
eng 
Print-ISSN:
1087-0156 
TUM Einrichtung:
III. Medizinische Klinik und Poliklinik