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Dokumenttyp:
journal article 
Autor(en):
von Bubnoff, N; Peschel, C; Duyster, J 
Titel:
Resistance of Philadelphia-chromosome positive leukemia towards the kinase inhibitor imatinib (STI571, Glivec): a targeted oncoprotein strikes back. 
Abstract:
Cancer research within the last decades elucidated signaling pathways and identified genes and proteins that lead or contribute to malignant transformation of a cell. Discovery of the Bcr-Abl oncoprotein as the molecular abnormality causing chronic myeloid leukemia (CML) paved the way for the development of a targeted anticancer therapy. The substantial activity of imatinib mesylate (STI571, Glivec) in CML and Philadelphia (Ph)-chromosome positive acute lymphoblastic leukemia (Ph+ ALL) changed t...    »
 
Zeitschriftentitel:
Leukemia 
Jahr:
2003 
Band / Volume:
17 
Heft / Issue:
Seitenangaben Beitrag:
829-38 
Sprache:
eng 
Print-ISSN:
0887-6924 
TUM Einrichtung:
III. Medizinische Klinik und Poliklinik