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Document type:
journal article 
Author(s):
Powolny-Budnicka, I; Riemann, M; Tänzer, S; Schmid, RM; Hehlgans, T; Weih, F 
Title:
RelA and RelB transcription factors in distinct thymocyte populations control lymphotoxin-dependent interleukin-17 production in ?? T cells. 
Abstract:
The NF-?B transcription factor regulates numerous immune responses but its contribution to interleukin-17 (IL-17) production by T cells is largely unknown. Here, we report that IL-17, but not interferon-? (IFN-?), production by ?? T cells required the NF-?B family members RelA and RelB as well as the lymphotoxin-?-receptor (LT?R). In contrast, LT?R-NF-?B signaling was not involved in the differentiation of conventional ?? Th17 cells. Impaired IL-17 production in RelA- or RelB-deficient T cells r...    »
 
Journal title abbreviation:
Immunity 
Year:
2011 
Journal volume:
34 
Journal issue:
Pages contribution:
364-74 
Language:
eng 
Print-ISSN:
1074-7613 
TUM Institution:
II. Medizinische Klinik und Poliklinik