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Dokumenttyp:
journal article 
Autor(en):
Geibel, J; Sritharan, K; Geibel, R; Geibel, P; Persing, JS; Seeger, A; Roepke, TK; Deichstetter, M; Prinz, C; Cheng, SX; Martin, D; Hebert, SC 
Titel:
Calcium-sensing receptor abrogates secretagogue- induced increases in intestinal net fluid secretion by enhancing cyclic nucleotide destruction. 
Abstract:
The calcium-sensing receptor (CaSR) provides a fundamental mechanism for diverse cells to detect and respond to modulations in the ionic and nutrient compositions of their extracellular milieu. The roles for this receptor are largely unknown in the intestinal tract, where epithelial cells are normally exposed to large variations in extracellular solutes. Here, we show that colonic CaSR signaling stimulates the degradation of cyclic nucleotides by phosphodiesterases and describe the ability of re...    »
 
Zeitschriftentitel:
Proc Natl Acad Sci U S A 
Jahr:
2006 
Band / Volume:
103 
Heft / Issue:
25 
Seitenangaben Beitrag:
9390-7 
Sprache:
eng 
Print-ISSN:
0027-8424 
TUM Einrichtung:
II. Medizinische Klinik und Poliklinik