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Dokumenttyp:
journal article 
Autor(en):
Schmidt, M; Hacein-Bey-Abina, S; Wissler, M; Carlier, F; Lim, A; Prinz, C; Glimm, H; Andre-Schmutz, I; Hue, C; Garrigue, A; Le Deist, F; Lagresle, C; Fischer, A; Cavazzana-Calvo, M; von Kalle, C 
Titel:
Clonal evidence for the transduction of CD34+ cells with lymphomyeloid differentiation potential and self-renewal capacity in the SCID-X1 gene therapy trial. 
Abstract:
Immune function has been restored in 9 of 10 children with X-linked severe combined immunodeficiency by gamma c gene transfer in CD34+ cells. The distribution of both T-cell receptor (TCR) V beta family usage and TCR V beta complementarity-determining region 3 (CDR3) length revealed a broadly diversified T-cell repertoire. Retroviral integration site analysis in T cells demonstrated a high number of distinct insertion sites, indicating polyclonality of genetically corrected cell clones, in all p...    »
 
Zeitschriftentitel:
Blood 
Jahr:
2005 
Band / Volume:
105 
Heft / Issue:
Seitenangaben Beitrag:
2699-706 
Sprache:
eng 
Print-ISSN:
0006-4971 
TUM Einrichtung:
II. Medizinische Klinik und Poliklinik