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Document type:
journal article 
Author(s):
von Wichert, G; Haeussler, U; Greten, FR; Kliche, S; Dralle, H; Böhm, BO; Adler, G; Seufferlein, T 
Title:
Regulation of cyclin D1 expression by autocrine IGF-I in human BON neuroendocrine tumour cells. 
Abstract:
Constitutive expression of cyclin D1 is a frequent abnormality in human cancer and sustains the transformed phenotype. We have previously demonstrated that cyclin D1 is constitutively expressed in human BON neuroendocrine tumour cells due to an autocrine insulin-like growth factor-I (IGF-I) loop. Here we examine the regulation of cyclin D1 expression by endogenously released IGF-I in BON cells. Cyclin D1 expression in these cells was found to be dependent on phosphatidylinositol 3-kinase (PI3-K)...    »
 
Journal title abbreviation:
Oncogene 
Year:
2005 
Journal volume:
24 
Journal issue:
Pages contribution:
1284-9 
Language:
eng 
Print-ISSN:
0950-9232 
TUM Institution:
II. Medizinische Klinik und Poliklinik