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Dokumenttyp:
journal article 
Autor(en):
Hasel, C; Dürr, S; Rau, B; Sträter, J; Schmid, RM; Walczak, H; Bachem, MG; Möller, P 
Titel:
In chronic pancreatitis, widespread emergence of TRAIL receptors in epithelia coincides with neoexpression of TRAIL by pancreatic stellate cells of early fibrotic areas. 
Abstract:
TRAIL (TNF-related apoptosis-inducing ligand) induces apoptosis by cross-linking of the two TRAIL receptors that contain a death domain, TRAIL-R1 and TRAIL-R2. TRAIL-R3 and TRAIL-R4 are receptors that do not transmit an apoptotic signal. Our aim was to determine the expression of TRAIL and its receptors in normal pancreas and chronic pancreatitis. We applied real-time PCR, immunohisto(cyto)chemistry, and nick-end labeling of apoptosis. In normal pancreas, a minor subset of acinar cells coexpress...    »
 
Zeitschriftentitel:
Lab Invest 
Jahr:
2003 
Band / Volume:
83 
Heft / Issue:
Seitenangaben Beitrag:
825-36 
Sprache:
eng 
Print-ISSN:
0023-6837 
TUM Einrichtung:
II. Medizinische Klinik und Poliklinik