N-terminal probrain natriuretic peptide and C-reactive protein in stable coronary heart disease.

Ndrepepa, G; Kastrati, A; Braun, S; Mehilli, J; Niemöller, K; von Beckerath, N; von Beckerath, O; Vogt, W; Schömig, A

doi:10.1016/j.amjmed.2005.10.060

journal article

Dokumenttyp:: Journal Article; Article
Autor(en):: Ndrepepa, G; Kastrati, A; Braun, S; Mehilli, J; Niemöller, K; von Beckerath, N; von Beckerath, O; Vogt, W; Schömig, A
Titel:: N-terminal probrain natriuretic peptide and C-reactive protein in stable coronary heart disease.
Abstract:: PURPOSE: C-reactive protein (CRP) and N-terminal pro-brain natriuretic peptide (NT-proBNP) provide prognostic information in patients with stable coronary heart disease. The aim of the study was to investigate whether combined use of NT-proBNP and CRP improves risk stratification in these patients. METHODS: This cohort study included 989 patients with stable coronary heart disease who underwent coronary stenting. CRP and NT-proBNP were measured before angiography. The primary end point of the study was all-cause mortality. Using median values of NT-proBNP (279.9 ng/L) and CRP (1.2 mg/L), patients were divided into 4 groups: low NT-proBNP-low CRP group (305 patients with NT-proBNP or =median; high NT-proBNP-low CRP group (237 patients with NT-proBNP> or =median and CRP or =median and CRP> or =median). RESULTS: During a median follow-up of 3.6 years (interquartile range 3.3 to 4.5 years), there were 85 deaths: 6 deaths in the low NT-proBNP-low CRP group, 11 deaths in the low NT-proBNP-high CRP group, 20 deaths in the high NT-proBNP-low CRP group, and 48 deaths in the high NT-proBNP-high CRP group with Kaplan-Meier mortality estimates of 2.7%, 8.9%, 12.1% and 35.6%, respectively (P <.001). Cox proportional hazards model showed that combination NT-proBNP-CRP was the strongest independent correlate of mortality (hazard ratio [HR] 4.3, 95% confidence interval [CI], 2.0-9.3; P <.001 for high NT-proBNP-high CRP vs low NT-proBNP-low CRP). CONCLUSION: Combined use of NT-proBNP and CRP improves long-term risk prediction of mortality in patients with stable coronary heart disease.
Zeitschriftentitel:: Am J Med
Jahr:: 2006
Band / Volume:: 119
Heft / Issue:: 4
Seitenangaben Beitrag:: 355.e1-8
Sprache:: eng
Volltext / DOI:: doi:10.1016/j.amjmed.2005.10.060
PubMed:: http://view.ncbi.nlm.nih.gov/pubmed/16564781
Print-ISSN:: 0002-9343
TUM Einrichtung:: I. Medizinische Klinik und Poliklinik (Kardiologie); Institut für Laboratoriumsmedizin (keine SAP-Zuordnung!)
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mediaTUM Gesamtbestand Einrichtungen Schools TUM School of Medicine and Health Departments Clinical Medicine Klinik und Poliklinik für Innere Medizin I, Kardiologie (Prof. Laugwitz)2006

mediaTUM Gesamtbestand Einrichtungen Schools TUM School of Medicine and Health Departments Clinical Medicine Lehr- und Forschungskooperationen mit den Kliniken und Instituten am Deutschen Herzzentrum Institut für Laboratoriumsmedizin (DHM) (Prof. Holdenrieder)2006