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Dokumenttyp:
journal article 
Autor(en):
Gawaz, M; Konrad, I; Hauser, AI; Sauer, S; Li, Z; Wester, HJ; Bengel, FM; Schwaiger, M; Schömig, A; Massberg, S; Haubner, R 
Titel:
Non-invasive imaging of glycoprotein VI binding to injured arterial lesions. 
Abstract:
Glycoprotein VI (GPVI) is the major platelet collagen receptor and plays a critical role in the process of thrombosis at sites of atherosclerotic lesions. This study evaluates the feasibility of radiolabeled soluble GPVI to identify injured arterial lesions. Radiolabeling was carried out using the iodogen method and resulted in the radioiodinated GPVI in radiochemical yields between 97-100%. The biodistribution of [(125)I]GPVI was determined in normal mice and demonstrated a blood clearance half...    »
 
Zeitschriftentitel:
Thromb Haemost 
Jahr:
2005 
Band / Volume:
93 
Heft / Issue:
Seitenangaben Beitrag:
910-3 
Sprache:
eng 
Print-ISSN:
0340-6245 
TUM Einrichtung:
I. Medizinische Klinik und Poliklinik; Nuklearmedizinische Klinik und Poliklinik