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Dokumenttyp:
journal article 
Autor(en):
Ott, I; Weigand, B; Michl, R; Seitz, I; Sabbari-Erfani, N; Neumann, FJ; Schömig, A 
Titel:
Tissue factor cytoplasmic domain stimulates migration by activation of the GTPase Rac1 and the mitogen-activated protein kinase p38. 
Abstract:
BACKGROUND: Tissue factor (TF), the surface receptor for the serine protease factor VIIa (FVIIa) and the initiator of the extrinsic coagulation cascade, supports vessel development and tumor metastasis by activation of extracellular, protease-dependent signaling pathways. The molecular mechanisms that do not require proteolytic activity of FVIIa are not yet known. The aim of the study, therefore, was to investigate the effects of active-site-inhibited FVIIa (FFR-FVIIa) on TF-mediated signaling....    »
 
Zeitschriftentitel:
Circulation 
Jahr:
2005 
Band / Volume:
111 
Heft / Issue:
Seitenangaben Beitrag:
349-55 
Sprache:
eng 
Print-ISSN:
0009-7322 
TUM Einrichtung:
I. Medizinische Klinik und Poliklinik