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Document type:
journal article 
Author(s):
Li, Z; Laugwitz, KL; Pinkernell, K; Pragst, I; Baumgartner, C; Hoffmann, E; Rosport, K; Münch, G; Moretti, A; Humrich, J; Lohse, MJ; Ungerer, M 
Title:
Effects of two Gbetagamma-binding proteins--N-terminally truncated phosducin and beta-adrenergic receptor kinase C terminus (betaARKct)--in heart failure. 
Abstract:
Myocardial overexpression of the C-terminus of beta-adrenergic receptor kinase (betaARKct) has been shown to result in a positive inotropic effect or an improvement of survival in heart failure. However, it is not clear whether this beneficial effect is mainly because of dominant-negative inhibition of betaARK1, and a consecutive resensitization of beta-adrenergic receptors (betaAR), or rather due to inhibition of other Gbetagamma-mediated effects. In this study, we tested whether overexpression...    »
 
Journal title abbreviation:
Gene Ther 
Year:
2003 
Journal volume:
10 
Journal issue:
16 
Pages contribution:
1354-61 
Language:
eng 
Print-ISSN:
0969-7128 
TUM Institution:
I. Medizinische Klinik und Poliklinik