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Dokumenttyp:
journal article 
Autor(en):
Ott, I; Vukovich, R; Schömig, A; Neumann, FJ 
Titel:
Overexpression of glycosyl phosphatidylinositol-anchored tissue factor pathway inhibitor-1 inhibits tissue factor activity. 
Abstract:
The cellular initiation of coagulation by the tissue factor (TF)-activated factor VII complex is transiently inhibited by endogenous tissue factor pathway inhibitor-1 (TFPI-1), whereas exogenously added TFPI-1 is targeted to a degradation pathway. This study investigates the relevance of glycosyl phosphatidylinositol (GPI) anchoring for the anticoagulant properties of TFPI-1. Experiments were performed with the human cell line ECV304 using liposomal gene transfer. For GPI anchoring of TFPI-1 we...    »
 
Zeitschriftentitel:
Blood Coagul Fibrinolysis 
Jahr:
2003 
Band / Volume:
14 
Heft / Issue:
Seitenangaben Beitrag:
539-44 
Sprache:
eng 
Print-ISSN:
0957-5235 
TUM Einrichtung:
I. Medizinische Klinik und Poliklinik