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Document type:
journal article 
Author(s):
Arking, DE; Pfeufer, A; Post, W; Kao, WH; Newton-Cheh, C; Ikeda, M; West, K; Kashuk, C; Akyol, M; Perz, S; Jalilzadeh, S; Illig, T; Gieger, C; Guo, CY; Larson, MG; Wichmann, HE; Marbán, E; O'Donnell, CJ; Hirschhorn, JN; Kääb, S; Spooner, PM; Meitinger, T; Chakravarti, A 
Title:
A common genetic variant in the NOS1 regulator NOS1AP modulates cardiac repolarization. 
Abstract:
Extremes of the electrocardiographic QT interval, a measure of cardiac repolarization, are associated with increased cardiovascular mortality. We identified a common genetic variant influencing this quantitative trait through a genome-wide association study on 200 subjects at the extremes of a population-based QT interval distribution of 3,966 subjects from the KORA cohort in Germany, with follow-up screening of selected markers in the remainder of the cohort. We validated statistically signific...    »
 
Journal title abbreviation:
Nat Genet 
Year:
2006 
Journal volume:
38 
Journal issue:
Pages contribution:
644-51 
Language:
eng 
Print-ISSN:
1061-4036 
TUM Institution:
Institut für Humangenetik