Benutzer: Gast  Login
Dokumenttyp:
journal article 
Autor(en):
Rivera, A; Fisher, SA; Fritsche, LG; Keilhauer, CN; Lichtner, P; Meitinger, T; Weber, BH 
Titel:
Hypothetical LOC387715 is a second major susceptibility gene for age-related macular degeneration, contributing independently of complement factor H to disease risk. 
Abstract:
Age-related macular degeneration (AMD) is a multifactorial disease and a prevalent cause of visual impairment in developed countries. Risk factors include environmental components and genetic determinants. The complement factor H (CFH) has been the first major susceptibility gene for AMD identified within 1q32. Here, we focused on a second region of interest in 10q26 where a recent meta-analysis revealed strongest evidence for linkage to AMD at a genome-wide significance level. Within an interva...    »
 
Zeitschriftentitel:
Hum Mol Genet 
Jahr:
2005 
Band / Volume:
14 
Heft / Issue:
21 
Seitenangaben Beitrag:
3227-36 
Sprache:
eng 
Print-ISSN:
0964-6906 
TUM Einrichtung:
r Humangenetik