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Document type:
journal article 
Author(s):
Rivera, A; Fisher, SA; Fritsche, LG; Keilhauer, CN; Lichtner, P; Meitinger, T; Weber, BH 
Title:
Hypothetical LOC387715 is a second major susceptibility gene for age-related macular degeneration, contributing independently of complement factor H to disease risk. 
Abstract:
Age-related macular degeneration (AMD) is a multifactorial disease and a prevalent cause of visual impairment in developed countries. Risk factors include environmental components and genetic determinants. The complement factor H (CFH) has been the first major susceptibility gene for AMD identified within 1q32. Here, we focused on a second region of interest in 10q26 where a recent meta-analysis revealed strongest evidence for linkage to AMD at a genome-wide significance level. Within an interva...    »
 
Journal title abbreviation:
Hum Mol Genet 
Year:
2005 
Journal volume:
14 
Journal issue:
21 
Pages contribution:
3227-36 
Language:
eng 
Print-ISSN:
0964-6906 
TUM Institution:
Institut für Humangenetik