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Dokumenttyp:
journal article 
Autor(en):
Rosemann, M; Kuosaite, V; Nathrath, M; Strom, TM; Quintanilla-Martinez, L; Richter, T; Imai, K; Atkinson, MJ 
Titel:
Allelic imbalance at intragenic markers of Tbx18 is a hallmark of murine osteosarcoma. 
Abstract:
We have recently identified a locus exhibiting a high frequency of allelic imbalance (AI) in both spontaneous human (HSA 6q14.1-15) and radiogenic murine (MMU9, 42 cM) osteosarcoma. Here we describe the fine mapping of the locus in osteosarcoma arising in (BALB/cxCBA) F(1) hybrid mice. These studies have allowed us to identify Tbx18, a member of the T-box transcriptional regulator gene family, as a candidate gene. Three intragenic Tbx18 polymorphisms were used to map the region of maximum AI to...    »
 
Zeitschriftentitel:
Carcinogenesis 
Jahr:
2003 
Band / Volume:
24 
Heft / Issue:
Seitenangaben Beitrag:
371-6 
Sprache:
eng 
Print-ISSN:
0143-3334 
TUM Einrichtung:
r Allgemeine Pathologie und pathologische Anatomie; Kinderklinik und Poliklinik; r Humangenetik