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Dokumenttyp:
journal article 
Autor(en):
Knopf, A; Plettenberg, C; Pickhard, A; Bas, M; Reifenberger, J; Bier, H; Balz, V 
Titel:
Analysis of the functional integrity of the p53 tumor-suppressor gene in malignant melanoma. 
Abstract:
Derogation of the p53 pathway is a hallmark in human malignancies but its implication in melanomas remains unclear. p53 is frequently accumulated in melanomas despite protein stabilizing mutations being rare. For a panel of six melanoma cell lines we performed transcript sequence analysis of the entire coding region and determined p53 protein stability and messenger RNA stability by western blot experiments and quantitative reverse-transcription-PCR, respectively. Transcript levels of p53 modify...    »
 
Zeitschriftentitel:
Melanoma Res 
Jahr:
2011 
Band / Volume:
21 
Heft / Issue:
Seitenangaben Beitrag:
380-8 
Sprache:
eng 
Print-ISSN:
0960-8931 
TUM Einrichtung:
Hals-, Nasen-, Ohrenklinik und Poliklinik