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Dokumenttyp:
journal article 
Autor(en):
Grammer, JB; Bleiziffer, S; Monticelli, F; Lange, R; Bauernschmitt, R 
Titel:
Calcineurin and matrix protein expression in cardiac hypertrophy: evidence for calcineurin B to control excessive hypertrophic signaling. 
Abstract:
In the compensatory state of human left ventricular hypertrophy (LVH), the remodeling processes in the extracellular matrix and the role of calcineurin (Cn) are not completely understood. The present work aimed to analyze the expression and activity of matrix metalloproteinases (MMPs), their endogenous inhibitors (TIMPs), and of Cn in patients with compensated LVH. By semiquantitative RT-PCR, Western blotting, and gelatine zymography, we determined mRNA, protein, and/or enzyme activity levels of...    »
 
Zeitschriftentitel:
Basic Res Cardiol 
Jahr:
2006 
Band / Volume:
101 
Heft / Issue:
Seitenangaben Beitrag:
292-300 
Sprache:
eng 
Print-ISSN:
0300-8428 
TUM Einrichtung:
chirurgie