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Document type:
journal article 
Author(s):
Zhang, L; Orban, M; Lorenz, M; Barocke, V; Braun, D; Urtz, N; Schulz, C; von Brühl, ML; Tirniceriu, A; Gaertner, F; Proia, RL; Graf, T; Bolz, SS; Montanez, E; Prinz, M; Müller, A; von Baumgarten, L; Billich, A; Sixt, M; Fässler, R; von Andrian, UH; Junt, T; Massberg, S 
Title:
A novel role of sphingosine 1-phosphate receptor S1pr1 in mouse thrombopoiesis. 
Abstract:
Millions of platelets are produced each hour by bone marrow (BM) megakaryocytes (MKs). MKs extend transendothelial proplatelet (PP) extensions into BM sinusoids and shed new platelets into the blood. The mechanisms that control platelet generation remain incompletely understood. Using conditional mutants and intravital multiphoton microscopy, we show here that the lipid mediator sphingosine 1-phosphate (S1P) serves as a critical directional cue guiding the elongation of megakaryocytic PP extensi...    »
 
Journal title abbreviation:
J Exp Med 
Year:
2012 
Journal volume:
209 
Journal issue:
12 
Pages contribution:
2165-81 
Language:
eng 
Print-ISSN:
0022-1007 
TUM Institution:
Klinik für Herz- und Kreislauferkrankungen