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Document type:
journal article 
Author(s):
Schönberger, T; Ziegler, M; Borst, O; Konrad, I; Nieswandt, B; Massberg, S; Ochmann, C; Jürgens, T; Seizer, P; Langer, H; Münch, G; Ungerer, M; Preissner, KT; Elvers, M; Gawaz, M 
Title:
The dimeric platelet collagen receptor GPVI-Fc reduces platelet adhesion to activated endothelium and preserves myocardial function after transient ischemia in mice. 
Abstract:
Platelets play a critical role in the pathophysiology of reperfusion, sepsis, and cardiovascular diseases. In a multiple step process, they adhere to activated endothelium and release proinflammatory cytokines thereby promoting the inflammatory process. Glycoprotein VI (GPVI) is the major collagen receptor on the platelet surface and triggers platelet activation and primary hemostasis. Activation of GPVI leads to stable platelet adhesion and degranulation of platelet granules. However, GPVI is c...    »
 
Journal title abbreviation:
Am J Physiol Cell Physiol 
Year:
2012 
Journal volume:
303 
Journal issue:
Pages contribution:
C757-66 
Language:
eng 
Print-ISSN:
0363-6143 
TUM Institution:
Klinik für Herz- und Kreislauferkrankungen