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- Dokumenttyp:
- Journal Article; Review; Review
- Autor(en):
- Eckel, F; Schneider, G; Schmid, RM
- Titel:
- Pancreatic cancer: a review of recent advances.
- Abstract:
- Pancreatic cancer is one of the most common causes of cancer-related death. Despite the advances of the molecular pathogenesis, pancreatic cancer remains a major unsolved health problem. Overall, the 5-year survival rate is < 5% and only approximately 20% of the 10% of patients with resectable disease survive 5 years. Recently, the European Study Group for Pancreatic Cancer 1 trial demonstrated substantially increased survival from adjuvant chemotherapy with 5-fluorouracil-folinic acid and preliminary data showed prolonged disease-free survival from adjuvant gemcitabine. Current palliative therapeutic approaches mostly focused on evaluating chemotherapy regimens in which gemcitabine is combined with a second cytotoxic agent. Recently, large randomised trials of combinations of gemcitabine with either capecitabine or with erlotinib demonstrated prolonged survival and 1-year survival rates of approximately 25%. The advance of molecular biology has led to the elucidation of molecular events that are important for pancreatic carcinogenesis and has provided a foundation for the development of novel chemotherapeutic and biological agents that appear to be promising and are likely to play a future role in the treatment of patients with advanced pancreatic cancer.
- Zeitschriftentitel:
- Expert Opin Investig Drugs
- Jahr:
- 2006
- Band / Volume:
- 15
- Heft / Issue:
- 11
- Seitenangaben Beitrag:
- 1395-410
- Sprache:
- eng
- Volltext / DOI:
- doi:10.1517/13543784.15.11.1395
- PubMed:
- http://view.ncbi.nlm.nih.gov/pubmed/17040199
- Print-ISSN:
- 1354-3784
- TUM Einrichtung:
- II. Medizinische Klinik und Poliklinik (Gastroenterologie)
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